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Starting with an empty hospital, the player must build rooms and hire doctors, nurses, handymen and receptionists. Diseases include Bloaty Head (which swells the patient's head), King Complex (which forces the patient to impersonate Elvis Presley), and Alien DNA (which transforms the patient into an alien). The game has a somewhat dark sense of humour, similar to that of its predecessor, Theme Park. The player is required to build an environment that will attract patients with comical diseases and then treat them while tending to their needs. Revival attempts have been made with the development of open-source remakes such as CorsixTH. The game was re-released on GOG.com in 2012 and Origin in 2015, and the PlayStation version was released on the PlayStation Network in Europe in 2008, Japan in 2009, and North America in 2010.

A Sega Saturn version was in development, but cancelled. Theme Hospital was a commercial success, selling over 4 million copies worldwide, and was ported to the PlayStation in 1998. The game received a generally positive reception, with reviewers praising the graphics and humour in particular. Multiplayer support with up to four players was added in a patch. Designers originally planned to include four distinct gameplay modes corresponding to historical time periods, but this was dropped due to time pressures on the team.

Peter Molyneux and James Leach came up with the idea of creating a Theme game based on a hospital, but Molyneux was not directly involved in development due to his work on Dungeon Keeper. The game is noted for its humour, and contains numerous references to pop culture. The game is the thematic successor to Theme Park, also produced by Bullfrog, and the second instalment in their Theme series, and part of their Designer Series.

Theme Hospital is a business simulation game developed by Bullfrog Productions and published by Electronic Arts in 1997 for MS-DOS and Microsoft Windows compatible PCs in which players design and operate a privately owned hospital with the goal of curing patients of fictitious comical ailments.

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